AlphaFold2 Algorithm

AlphaFold2 Algorithm

Enter AlphaFold2

• Google’s DeepMind team Entered AlphaFold 2 in CASP14
• Achieved a median Global Distance Test Score of 92.4
  • This score essentially says: How close is my predicited structure to the known structure?

AlphaFold2 Algorithm

• AlphaFold 2 works by:
  • starts with a user's query protein sequence
  • finding similar sequences to that query
  • aligns these sequences to create a mutliple sequence alignment
  • uses available structure data based on query sequence to create initial distances between residues
  • uses a neural network to iteratively update the distances between residues by using information from the sequence alignment
  • passes this to another neural network to determine how these residues are oriented in 3D space